Naloxone blockade of amphetamine place preference conditioning
نویسندگان
چکیده
منابع مشابه
Amphetamine Conditioned Place Preference in Planarians
Methand other amphetamines currently present major drug-abuse concerns. However, the demonstration and study of abuse-related behaviors expressed in animal models is expensive and time-consuming. We previously reported a novel model of conditioned place preference (CPP), which is a standard tool in abuse research, in invertebrates (planarians). In the present study, planarians were tested for l...
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Downward phase of dose-response morphine converted U shape curve was chosen as a base for investigating the effects of different doses of naloxone (0.05-0.4 mg/Kg) on morphine reward/aversion properties using place preference method. First, male Wistar rats (200-220 g) were received morphine (1-7.5 mg/Kg) for place conditioning and marginal dose of morphine (5 mg/Kg) calculated by GraphPad soft...
متن کاملBiphasic Effects of Naloxone in the Rats Receiving Morphine Overdose A Place Preference Study
Downward phase of dose-response morphine converted U shape curve was chosen as a base for investigating the effects of different doses of naloxone (0.05-0.4 mg/Kg) on morphine reward/aversion properties using place preference method. First, male Wistar rats (200-220 g) were received morphine (1-7.5 mg/Kg) for place conditioning and marginal dose of morphine (5 mg/Kg) calculated by GraphPad soft...
متن کاملPharmacology of sucrose-reinforced place-preference conditioning: effects of naltrexone.
Two experiments investigated the role of the opioid system in sucrose-reinforced conditioned place preferences (CPPs) in rats. Experiment 1 examined the effects of a general opioid antagonist, naltrexone, on the expression of a CPP acquired in the absence of the drug. Subjects were trained to associate one compartment of a two-compartment chamber with sucrose and the other compartment with wate...
متن کاملInvolvement of dopamine receptors in diethylpropion-induced conditioning place preference.
Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. After initial preferences were determined, animals weighing 250-300 g (N = 7 per group) were cond...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 1991
ISSN: 0033-3158,1432-2072
DOI: 10.1007/bf02244190